The Acute HIV Infection Research Program at MGH is based out of the Ragon Institute of MGH, MIT and Harvard in Charlestown, MA and the Infectious Disease Unit at Massachusetts General Hospital (MGH). It reflects a 
close collaboration among HIV scientists, patients and healthcare professionals in the Boston area, nationally and abroad.
While our main, local enrollment sites are MGH and Fenway Health, we also have productive collaborations with HIV research and clinical care organizations in Berlin, Germany and Durban, South Africa. The Broad Institute and SAIC-Frederick are also our close research collaborators.
We are funded by two large National Institutes of Health (NIH) grants:
1) P01 AI074415: Acute HIV Infection: Implications for Vaccine Design (Observational Study)
Co-Principal Investigators:
Dr. Todd Allen
Dr. Marcus Altfeld
Project Leaders:
Project 1: Recognition of HIV-1 by Innate Immunity Receptors during Acute HIV-1 Infection
Project 2: Adaptive Immunity in Acute HIV-1 Infection
Drs. Bruce Walker and Sylvie Legall
Project 3: Identifying Acute Phase CTL Escape Mutations and their Impact on HIV-1 Fitness
Project 4: Alteration of Dendritic Cell Function by Early HIV-1 CTL Escape Mutations
Project Biostatistician:
2) R01 AI071915: A Clinical Trial to Evaluate the Initiation of Treatment vs. No Treatment during Acute HIV-1 Infection
Principal Investigator:
Co-Investigator:
Clinical Trial Specialist:
Sue Bazner, R.N., N.P.
Project Immunologist:
Dr. Marcus Altfeld
Project Virologist:
Dr. Todd Allen
